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Target
Interstitial collagenase
Ligand
BDBM50107582
Substrate
n/a
Meas. Tech.
ChEBML_106318
Ki
>5000±n/a nM
Citation
 Yao, W; Chao, M; Wasserman, ZR; Liu, RQ; Covington, MB; Newton, R; Christ, D; Wexler, RR; Decicco, CP Potent P1' biphenylmethyl substituted aggrecanase inhibitors. Bioorg Med Chem Lett 12:101-4 (2001) [PubMed]  Article 
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
  
Inhibitor
Name:
BDBM50107582
Synonyms:
(R)-N*4*-Hydroxy-N*1*-((1S,2R)-2-hydroxy-indan-1-yl)-2-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-succinamide | CHEMBL268680
Type:
Small organic molecule
Emp. Form.:
C27H26N6O4
Mol. Mass.:
498.5331
SMILES:
ONC(=O)C[C@@H](Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12
Structure:
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