Reaction Details Report a problem with these data
Target
Inosine-5'-monophosphate dehydrogenase
Ligand
BDBM50548456
Substrate
n/a
Meas. Tech.
ChEMBL_2022366 (CHEMBL4676179)
Ki
2800±n/a nM
Citation
 Lee, S; Ku, AF; Vippila, MR; Wang, Y; Zhang, M; Wang, X; Hedstrom, L; Cuny, GD Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article 
Target
Name:
Inosine-5'-monophosphate dehydrogenase
Synonyms:
Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH)
Type:
Protein
Mol. Mass.:
43076.80
Organism:
Cryptosporidium parvum
Description:
Q8T6T2
Residue:
400
Sequence:
MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
  
Inhibitor
Name:
BDBM50548456
Synonyms:
CHEMBL4760324
Type:
Small organic molecule
Emp. Form.:
C20H20ClNO5
Mol. Mass.:
389.83
SMILES:
COc1c(C)c2COC(=O)c2c(O)c1CCCC(=O)Nc1ccc(Cl)cc1
Structure:
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