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Target
Dihydrofolate reductase
Ligand
BDBM50050403
Substrate
n/a
Meas. Tech.
ChEMBL_54089 (CHEMBL669986)
IC50
36±n/a nM
Citation
 Debnath, AK Pharmacophore mapping of a series of 2,4-diamino-5-deazapteridine inhibitors of Mycobacterium avium complex dihydrofolate reductase. J Med Chem 45:41-53 (2001) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21453.99
Organism:
Homo sapiens (Human)
Description:
Recombinant human DHFR.
Residue:
187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
  
Inhibitor
Name:
BDBM50050403
Synonyms:
6-{[(2-Methoxy-5-trifluoromethyl-phenyl)-methyl-amino]-methyl}-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine | CHEMBL23076
Type:
Small organic molecule
Emp. Form.:
C18H19F3N6O
Mol. Mass.:
392.3783
SMILES:
COc1ccc(cc1N(C)Cc1cnc2nc(N)nc(N)c2c1C)C(F)(F)F
Structure:
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