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Target
D(1B) dopamine receptor
Ligand
BDBM50549180
Substrate
n/a
Meas. Tech.
ChEMBL_2024044 (CHEMBL4677857)
EC50
168±n/a nM
Citation
 Luderman, KD; Jain, P; Benjamin Free, R; Conroy, JL; Aubé, J; Sibley, DR; Frankowski, KJ Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett 31:0 (2021) [PubMed]  Article 
Target
Name:
D(1B) dopamine receptor
Synonyms:
D(5) dopamine receptor | D1beta dopamine receptor | DOPAMINE D5 | DRD1B | DRD1L2 | DRD5 | DRD5_HUMAN | dopamine receptor D5
Type:
Protein
Mol. Mass.:
52943.41
Organism:
Homo sapiens (Human)
Description:
P21918
Residue:
477
Sequence:
MLPPGSNGTAYPGQFALYQQLAQGNAVGGSAGAPPLGPSQVVTACLLTLLIIWTLLGNVLVCAAIVRSRHLRANMTNVFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCSTASILNLCVISVDRYWAISRPFRYKRKMTQRMALVMVGLAWTLSILISFIPVQLNWHRDQAASWGGLDLPNNLANWTPWEEDFWEPDVNAENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSSAACAPDTSLRASIKKETKVLKTLSVIMGVFVCCWLPFFILNCMVPFCSGHPEGPPAGFPCVSETTFDVFVWFGWANSSLNPVIYAFNADFQKVFAQLLGCSHFCSRTPVETVNISNELISYNQDIVFHKEIAAAYIHMMPNAVTPGNREVDNDEEEGPFDRMFQIYQTSPDGDPVAESVWELDCEGEISLDKITPFTPNGFH
  
Inhibitor
Name:
BDBM50549180
Synonyms:
CHEMBL4740497
Type:
Small organic molecule
Emp. Form.:
C26H27N3O2
Mol. Mass.:
413.5115
SMILES:
Cc1ccc(cc1)-n1c(CC2CCCCC2)nc2n(C)c3ccccc3c(=O)c2c1=O
Structure:
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