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Target
D(1A) dopamine receptor
Ligand
BDBM50549189
Substrate
n/a
Meas. Tech.
ChEMBL_2024046 (CHEMBL4677859)
EC50
150±n/a nM
Citation
 Luderman, KD; Jain, P; Benjamin Free, R; Conroy, JL; Aubé, J; Sibley, DR; Frankowski, KJ Development of pyrimidone D1 dopamine receptor positive allosteric modulators. Bioorg Med Chem Lett 31:0 (2021) [PubMed]  Article 
Target
Name:
D(1A) dopamine receptor
Synonyms:
DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A
Type:
Enzyme
Mol. Mass.:
49303.43
Organism:
Homo sapiens (Human)
Description:
P21728
Residue:
446
Sequence:
MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
  
Inhibitor
Name:
BDBM50549189
Synonyms:
CHEMBL4756163
Type:
Small organic molecule
Emp. Form.:
C23H23N3O3
Mol. Mass.:
389.447
SMILES:
COc1ccc(cc1)-n1c(CC(C)C)nc2n(C)c3ccccc3c(=O)c2c1=O
Structure:
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