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Target
Proteasome subunit beta type-8
Ligand
BDBM50234984
Substrate
n/a
Meas. Tech.
ChEMBL_2024063 (CHEMBL4677876)
IC50
1.1±n/a nM
Citation
 Zhao, Y; Xu, L; Zhang, J; Zhang, M; Lu, J; He, R; Xi, J; Zhuang, R; Li, J; Zhou, Y Optimization of piperidine constructed peptidyl derivatives as proteasome inhibitors. Bioorg Med Chem 29:0 (2021) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50234984
Synonyms:
CHEMBL3218837
Type:
Small organic molecule
Emp. Form.:
C34H37ClN6O5
Mol. Mass.:
645.148
SMILES:
CC(C)(C)CNC(=O)C[C@H](NC(=O)C(=O)c1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccncc1)C(=O)NCc1ccccc1Cl |r|
Structure:
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