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Target
Glycine receptor subunit alpha-4
Ligand
BDBM50108653
Substrate
n/a
Meas. Tech.
ChEMBL_70971 (CHEMBL857373)
IC50
>10000±n/a nM
Citation
 Maier, CA; Wünsch, B Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1. J Med Chem 45:438-48 (2002) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-4
Synonyms:
GLRA4_MOUSE | Glra4 | Glycine receptor alpha-4 chain
Type:
PROTEIN
Mol. Mass.:
52521.54
Organism:
Mus musculus
Description:
ChEMBL_70971
Residue:
456
Sequence:
MTTLVPASLFLLLWTLPGKVLLSVALAKEDVKSGLKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNVFLRQQWNDPRLAYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCPMDLKNFPMDIQTCTMQLESFGYTMNDLMFEWLEDAPAVQVAEGLTLPQFILRDEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFMRLRRRQRRQRMEEDIIRESRFYFRGYGLGHCLQARDGGPMEGSSIYSPQPPTPLLKEGETMRKLYVDRAKRIDTISRAVFPFTFLVFNIFYWVVYKVLRSEDIHQAL
  
Inhibitor
Name:
BDBM50108653
Synonyms:
1'-benzyl-3-methoxyspiro[3,4-dihydro-1H-isochromene-1,4'-(hexahydropyridine)] | 1'-benzyl-3-methoxyspiro[isochroman-1,4'-piperidine] | CHEMBL141209
Type:
Small organic molecule
Emp. Form.:
C21H25NO2
Mol. Mass.:
323.4287
SMILES:
COC1Cc2ccccc2C2(CCN(Cc3ccccc3)CC2)O1
Structure:
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