Reaction Details Report a problem with these data
Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM50549789
Substrate
n/a
Meas. Tech.
ChEMBL_2025815 (CHEMBL4679628)
IC50
2200±n/a nM
Citation
 Bum-Erdene, K; Liu, D; Xu, D; Ghozayel, MK; Meroueh, SO Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR·uPA Interaction. ACS Med Chem Lett 12:60-66 (2021) [PubMed]  Article 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor
Type:
Receptor
Mol. Mass.:
36979.14
Organism:
Homo sapiens (Human)
Description:
Q03405
Residue:
335
Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
  
Inhibitor
Name:
BDBM50549789
Synonyms:
CHEMBL4752534
Type:
Small organic molecule
Emp. Form.:
C25H22N2O3S
Mol. Mass.:
430.519
SMILES:
COc1ccc(cc1)-c1cc(C(=O)N2CCOCC2)c2cccc(-c3cccs3)c2n1
Structure:
Search PDB for entries with ligand similarity: