Reaction Details Report a problem with these data
Target
Urokinase plasminogen activator surface receptor
Ligand
BDBM50549795
Substrate
n/a
Meas. Tech.
ChEMBL_2025815 (CHEMBL4679628)
IC50
73800±n/a nM
Citation
 Bum-Erdene, K; Liu, D; Xu, D; Ghozayel, MK; Meroueh, SO Design and Synthesis of Fragment Derivatives with a Unique Inhibition Mechanism of the uPAR·uPA Interaction. ACS Med Chem Lett 12:60-66 (2021) [PubMed]  Article 
Target
Name:
Urokinase plasminogen activator surface receptor
Synonyms:
CD_antigen=CD87 | MO3 | Monocyte activation antigen Mo3 | PLAUR | U-PAR | UPAR | UPAR_HUMAN | Urokinase plasminogen activator surface receptor | Urokinase receptor (uPAR) | Urokinase-type plasminogen activator/surface receptor
Type:
Receptor
Mol. Mass.:
36979.14
Organism:
Homo sapiens (Human)
Description:
Q03405
Residue:
335
Sequence:
MGHPPLLPLLLLLHTCVPASWGLRCMQCKTNGDCRVEECALGQDLCRTTIVRLWEEGEELELVEKSCTHSEKTNRTLSYRTGLKITSLTEVVCGLDLCNQGNSGRAVTYSRSRYLECISCGSSDMSCERGRHQSLQCRSPEEQCLDVVTHWIQEGEEGRPKDDRHLRGCGYLPGCPGSNGFHNNDTFHFLKCCNTTKCNEGPILELENLPQNGRQCYSCKGNSTHGCSSEETFLIDCRGPMNQCLVATGTHEPKNQSYMVRGCATASMCQHAHLGDAFSMNHIDVSCCTKSGCNHPDLDVQYRSGAAPQPGPAHLSLTITLLMTARLWGGTLLWT
  
Inhibitor
Name:
BDBM50549795
Synonyms:
CHEMBL4748990
Type:
Small organic molecule
Emp. Form.:
C28H21N3O4
Mol. Mass.:
463.484
SMILES:
O=C(N1CCOCC1)c1cc(nc2c(cccc12)N1C(=O)c2ccccc2C1=O)-c1ccccc1
Structure:
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