Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50549931
Substrate
n/a
Meas. Tech.
ChEMBL_2026002 (CHEMBL4679815)
IC50
63±n/a nM
Citation
 Schrader, TO; Xiong, Y; Lorenzana, AO; Broadhead, A; Stebbins, KJ; Poon, MM; Baccei, C; Lorrain, DS Discovery of PIPE-359, a Brain-Penetrant, Selective M ACS Med Chem Lett 12:155-161 (2021) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50549931
Synonyms:
CHEMBL4755998
Type:
Small organic molecule
Emp. Form.:
C23H25FN4O
Mol. Mass.:
392.4692
SMILES:
Cc1cc(F)cnc1N1CCN(CC1)C(=O)CCCc1cccc2ncccc12
Structure:
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