Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50549926
Substrate
n/a
Meas. Tech.
ChEMBL_2026002 (CHEMBL4679815)
IC50
20±n/a nM
Citation
 Schrader, TO; Xiong, Y; Lorenzana, AO; Broadhead, A; Stebbins, KJ; Poon, MM; Baccei, C; Lorrain, DS Discovery of PIPE-359, a Brain-Penetrant, Selective M ACS Med Chem Lett 12:155-161 (2021) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50549926
Synonyms:
CHEMBL4783670
Type:
Small organic molecule
Emp. Form.:
C24H28N4O
Mol. Mass.:
388.5053
SMILES:
C[C@@H]1CN(CCN1C(=O)CCCc1cccc2ncccc12)c1cnccc1C |r|
Structure:
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