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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50099023
Substrate
n/a
Meas. Tech.
ChEMBL_71579 (CHEMBL684239)
IC50
7±n/a nM
Citation
 Zhu, YF; Struthers, RS; Connors, PJ; Gao, Y; Gross, TD; Saunders, J; Wilcoxen, K; Reinhart, GJ; Ling, N; Chen, C Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists. Bioorg Med Chem Lett 12:399-402 (2002) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50099023
Synonyms:
CHEMBL11149 | N-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)-1H-indol-3-yl]-ethylamino}-butyl)-phenyl]-methanesulfonamide | N-[4-(4-{2-[2-(3,5-Dimethyl-phenyl)-2,3-dihydro-1H-indol-3-yl]-ethylamino}-butyl)-phenyl]-methanesulfonamide
Type:
Small organic molecule
Emp. Form.:
C29H35N3O2S
Mol. Mass.:
489.672
SMILES:
Cc1cc(C)cc(c1)-c1[nH]c2ccccc2c1CCNCCCCc1ccc(NS(C)(=O)=O)cc1
Structure:
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