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Target
Glucagon receptor
Ligand
BDBM50109320
Substrate
n/a
Meas. Tech.
ChEBML_72877
IC50
9000±n/a nM
Citation
 Ladouceur, GH; Cook, JH; Doherty, EM; Schoen, WR; MacDougall, ML; Livingston, JN Discovery of 5-hydroxyalkyl-4-phenylpyridines as a new class of glucagon receptor antagonists. Bioorg Med Chem Lett 12:461-4 (2002) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50109320
Synonyms:
CHEMBL436011 | [4-(4-Fluoro-phenyl)-2,6-diisopropyl-5-methoxymethyl-pyridin-3-yl]-methanol
Type:
Small organic molecule
Emp. Form.:
C20H26FNO2
Mol. Mass.:
331.4243
SMILES:
COCc1c(nc(C(C)C)c(CO)c1-c1ccc(F)cc1)C(C)C
Structure:
Search PDB for entries with ligand similarity: