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Target
Urokinase-type plasminogen activator
Ligand
BDBM50109373
Substrate
n/a
Meas. Tech.
ChEBML_212981
Ki
1520±n/a nM
Citation
 Rudolph, MJ; Illig, CR; Subasinghe, NL; Wilson, KJ; Hoffman, JB; Randle, T; Green, D; Molloy, CJ; Soll, RM; Lewandowski, F; Zhang, M; Bone, R; Spurlino, JC; Deckman, IC; Manthey, C; Sharp, C; Maguire, D; Grasberger, BL; DesJarlais, RL; Zhou, Z Design and synthesis of 4,5-disubstituted-thiophene-2-amidines as potent urokinase inhibitors. Bioorg Med Chem Lett 12:491-5 (2002) [PubMed]  Article 
Target
Name:
Urokinase-type plasminogen activator
Synonyms:
3.4.21.73 | PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator chain B | Urokinase-type plasminogen activator long chain A | Urokinase-type plasminogen activator short chain A | Urokinase-type plasminogen activator/surface receptor | uPA
Type:
Enzyme
Mol. Mass.:
48528.62
Organism:
Homo sapiens (Human)
Description:
P00749
Residue:
431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL
  
Inhibitor
Name:
BDBM50109373
Synonyms:
5-(4-Methoxy-benzylsulfanyl)-4-(4-phenyl-thiazol-2-yl)-thiophene-2-carboxamidine | CHEMBL423756
Type:
Small organic molecule
Emp. Form.:
C22H19N3OS3
Mol. Mass.:
437.601
SMILES:
COc1ccc(CSc2sc(cc2-c2nc(cs2)-c2ccccc2)C(N)=N)cc1
Structure:
Search PDB for entries with ligand similarity: