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Target
Protein arginine N-methyltransferase 7
Ligand
BDBM50550091
Substrate
n/a
Meas. Tech.
ChEMBL_2026417 (CHEMBL4680575)
IC50
23600±n/a nM
Citation
 Qian, K; Yan, C; Su, H; Dang, T; Zhou, B; Wang, Z; Zhao, X; Ivanov, I; Ho, MC; Zheng, YG Pharmacophore-based screening of diamidine small molecule inhibitors for protein arginine methyltransferases. RSC Med Chem 12:95-102 (2021) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 7
Synonyms:
ANM7_HUMAN | Histone-arginine N-methyltransferase PRMT7 | KIAA1933 | PRMT7 | Protein arginine N-methyltransferase 7 | Protein arginine methyltransferase 7 (PRMT7) | [Myelin basic protein]-arginine N-methyltransferase PRMT7
Type:
Enzyme
Mol. Mass.:
78440.77
Organism:
Homo sapiens (Human)
Description:
Q9NVM4
Residue:
692
Sequence:
MKIFCSRANPTTGSVEWLEEDEHYDYHQEIARSSYADMLHDKDRNVKYYQGIRAAVSRVKDRGQKALVLDIGTGTGLLSMMAVTAGADFCYAIEVFKPMADAAVKIVEKNGFSDKIKVINKHSTEVTVGPEGDMPCRANILVTELFDTELIGEGALPSYEHAHRHLVEENCEAVPHRATVYAQLVESGRMWSWNKLFPIHVQTSLGEQVIVPPVDVESCPGAPSVCDIQLNQVSPADFTVLSDVLPMFSIDFSKQVSSSAACHSRRFEPLTSGRAQVVLSWWDIEMDPEGKIKCTMAPFWAHSDPEEMQWRDHWMQCVYFLPQEEPVVQGSALYLVAHHDDYCVWYSLQRTSPEKNERVRQMRPVCDCQAHLLWNRPRFGEINDQDRTDRYVQALRTVLKPDSVCLCVSDGSLLSVLAHHLGVEQVFTVESSAASHKLLRKIFKANHLEDKINIIEKRPELLTNEDLQGRKVSLLLGEPFFTTSLLPWHNLYFWYVRTAVDQHLGPGAMVMPQAASLHAVVVEFRDLWRIRSPCGDCEGFDVHIMDDMIKRALDFRESREAEPHPLWEYPCRSLSEPWQILTFDFQQPVPLQPLCAEGTVELRRPGQSHAAVLWMEYHLTPECTLSTGLLEPADPEGGCCWNPHCKQAVYFFSPAPDPRALLGGPRTVSYAVEFHPDTGDIIMEFRHADTPD
  
Inhibitor
Name:
BDBM50550091
Synonyms:
CHEMBL4648477
Type:
Small organic molecule
Emp. Form.:
C22H20N6
Mol. Mass.:
368.4344
SMILES:
NC(=N)c1ccc(Nc2ccc(cc2)-c2cc3ccc(cc3[nH]2)C(N)=N)cc1
Structure:
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