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Target
Serine/threonine-protein kinase RIO2
Ligand
BDBM50550130
Substrate
n/a
Meas. Tech.
ChEMBL_2026439 (CHEMBL4680597)
IC50
13400±n/a nM
Citation
 Wang, CB; Lorente-Macías, Á; Wells, C; Pickett, JE; Picado, A; Zuercher, WJ; Axtman, AD Towards a RIOK2 chemical probe: cellular potency improvement of a selective 2-(acylamino)pyridine series. RSC Med Chem 12:129-136 (2021) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase RIO2
Synonyms:
RIO2 | RIOK2 | RIOK2_HUMAN
Type:
PROTEIN
Mol. Mass.:
63275.25
Organism:
Homo sapiens (Human)
Description:
ChEMBL_655912
Residue:
552
Sequence:
MGKVNVAKLRYMSRDDFRVLTAVEMGMKNHEIVPGSLIASIASLKHGGCNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVEDPASVYDEAMELIVKLANHGLIHGDFNEFNLILDESDHITMIDFPQMVSTSHPNAEWYFDRDVKCIKDFFMKRFSYESELFPTFKDIRREDTLDVEVSASGYTKEMQADDELLHPLGPDDKNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRSSGDPEQIKEDSLSEESADARSFEMTEFNQALEEIKGQVVENNSVTEFSEEKNRTENYNRQDGQRVQGGVPAGSDEYEDECPHLIALSSLNREFRPFRDEENVGAMNQYRTRTLSITSSGSAVSCSTIPPELVKQKVKRQLTKQQKSAVRRRLQKGEANIFTKQRRENMQNIKSSLEAASFWGE
  
Inhibitor
Name:
BDBM50550130
Synonyms:
CHEMBL4785960
Type:
Small organic molecule
Emp. Form.:
C17H13BrN2O
Mol. Mass.:
341.202
SMILES:
Brc1ccnc(NC(=O)Cc2ccc3ccccc3c2)c1
Structure:
Search PDB for entries with ligand similarity: