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Target
Baculoviral IAP repeat-containing protein 5
Ligand
BDBM50209194
Substrate
n/a
Meas. Tech.
ChEMBL_2026475 (CHEMBL4680633)
Kd
44±n/a nM
Citation
 Fuchigami, T; Mizoguchi, T; Ishikawa, N; Haratake, M; Yoshida, S; Magata, Y; Nakayama, M Synthesis and evaluation of a radioiodinated 4,6-diaryl-3-cyano-2-pyridinone derivative as a survivin targeting SPECT probe for tumor imaging. Bioorg Med Chem Lett 26:999-1004 (2016) [PubMed]  Article 
Target
Name:
Baculoviral IAP repeat-containing protein 5
Synonyms:
API4 | Apoptosis inhibitor 4 | Apoptosis inhibitor survivin | BIRC5 | BIRC5_HUMAN | IAP4
Type:
PROTEIN
Mol. Mass.:
16386.52
Organism:
Homo sapiens (Human)
Description:
ChEMBL_443470
Residue:
142
Sequence:
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETAKKVRRAIEQLAAMD
  
Inhibitor
Name:
BDBM50209194
Synonyms:
CHEMBL234358 | N-(5-chloro-3-(4-(2-chloro-5-(trifluoromethyl)phenyl)-5-cyano-6-oxo-1,6-dihydropyridin-2-yl)-2-hydroxybenzyl)-N-methyl-1-propylpiperidine-4-carboxamide
Type:
Small organic molecule
Emp. Form.:
C30H29Cl2F3N4O3
Mol. Mass.:
621.477
SMILES:
CCCN1CCC(CC1)C(=O)N(C)Cc1cc(Cl)cc(c1O)-c1cc(-c2cc(ccc2Cl)C(F)(F)F)c(C#N)c(=O)[nH]1
Structure:
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