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Target
Amphiregulin
Ligand
BDBM50291705
Substrate
n/a
Meas. Tech.
ChEMBL_217975 (CHEMBL824094)
IC50
970±n/a nM
Citation
 Sawa, M; Tsukamoto, T; Kiyoi, T; Kurokawa, K; Nakajima, F; Nakada, Y; Yokota, K; Inoue, Y; Kondo, H; Yoshino, K New strategy for antedrug application: development of metalloproteinase inhibitors as antipsoriatic drugs. J Med Chem 45:930-6 (2002) [PubMed]  Article 
Target
Name:
Amphiregulin
Synonyms:
AREG | AREGB | AREG_HUMAN | SDGF
Type:
PROTEIN
Mol. Mass.:
27898.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_217975
Residue:
252
Sequence:
MRAPLLPPAPVVLSLLILGSGHYAAGLDLNDTYSGKREPFSGDHSADGFEVTSRSEMSSGSEISPVSEMPSSSEPSSGADYDYSEEYDNEPQIPGYIVDDSVRVEQVVKPPQNKTESENTSDKPKRKKKGGKNGKNRRNRKKKNPCNAEFQNFCIHGECKYIEHLEAVTCKCQQEYFGERCGEKSMKTHSMIDSSLSKIALAAIAAFMSAVILTAVAVITVQLRRQYVRKYEGEAEERKKLRQENGNVHAIA
  
Inhibitor
Name:
BDBM50291705
Synonyms:
(S)-((R)-3-Hydroxycarbamoyl-3,4-dihydro-1H-isoquinolin-2-yl)-(4-methoxy-phenyl)-phosphinic acid 3,3,3-trifluoro-propyl ester | CHEMBL64689
Type:
Small organic molecule
Emp. Form.:
C20H22F3N2O5P
Mol. Mass.:
458.3681
SMILES:
COc1ccc(cc1)[P@@](=O)(OCCC(F)(F)F)N1Cc2ccccc2C[C@@H]1C(=O)NO
Structure:
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