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Target
Glucagon receptor
Ligand
BDBM50110068
Substrate
n/a
Meas. Tech.
ChEBML_72874
IC50
23±n/a nM
Citation
 Ling, A; Plewe, M; Gonzalez, J; Madsen, P; Sams, CK; Lau, J; Gregor, V; Murphy, D; Teston, K; Kuki, A; Shi, S; Truesdale, L; Kiel, D; May, J; Lakis, J; Anderes, K; Iatsimirskaia, E; Sidelmann, UG; Knudsen, LB; Brand, CL; Polinsky, A Human glucagon receptor antagonists based on alkylidene hydrazides. Bioorg Med Chem Lett 12:663-6 (2002) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50110068
Synonyms:
3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-benzyloxy)-3,5-dimethoxy-phenyl]-meth-(E)-ylidene]-hydrazide | CHEMBL348785 | N'-(4-(4-isopropylbenzyloxy)-3,5-dimethoxybenzylidene)-3-chloro-4-hydroxybenzohydrazide
Type:
Small organic molecule
Emp. Form.:
C26H27ClN2O5
Mol. Mass.:
482.956
SMILES:
COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Structure:
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