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Target
Protein disulfide-isomerase A6
Ligand
BDBM50550836
Substrate
n/a
Meas. Tech.
ChEMBL_2028623 (CHEMBL4682781)
IC50
16300±n/a nM
Citation
 Robinson, RM; Reyes, L; Duncan, RM; Bian, H; Strobel, ED; Hyman, SL; Reitz, AB; Dolloff, NG Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. Eur J Med Chem 186:0 (2020) [PubMed]  Article 
Target
Name:
Protein disulfide-isomerase A6
Synonyms:
5.3.4.1 | ER protein 5 | ERP5 | Endoplasmic reticulum protein 5 | P5 | PDIA6 | PDIA6_HUMAN | Protein disulfide isomerase P5 | Protein disulfide-isomerase A6 | TXNDC7 | Thioredoxin domain-containing protein 7
Type:
PROTEIN
Mol. Mass.:
48106.63
Organism:
Homo sapiens
Description:
ChEMBL_105136
Residue:
440
Sequence:
MALLVLGLVSCTFFLAVNGLYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAATALKDVVKVGAVDADKHHSLGGQYGVQGFPTIKIFGSNKNRPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRSDSSSKKDVIELTDDSFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAASEVKEQTKGKVKLAAVDATVNQVLASRYGIRGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKRTCEEHQLCVVAVLPHILDTGAAGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQSELETALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGAFPTIVEREPWDGRDGELPVEDDIDLSDVELDDLGKDEL
  
Inhibitor
Name:
BDBM50550836
Synonyms:
CHEMBL4751241
Type:
Small organic molecule
Emp. Form.:
C21H27F3O2
Mol. Mass.:
368.4331
SMILES:
CCCCCCCC\C=C1\C=C(c2cc(OC)c(OC)cc12)C(F)(F)F |c:10|
Structure:
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