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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50550978
Substrate
n/a
Meas. Tech.
ChEMBL_2029451 (CHEMBL4683609)
EC50
1450±n/a nM
Citation
 Li, G; Meng, B; Yuan, B; Huan, Y; Zhou, T; Jiang, Q; Lei, L; Sheng, L; Wang, W; Gong, N; Lu, Y; Ma, C; Li, Y; Shen, Z; Huang, H The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem 188:0 (2020) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50550978
Synonyms:
CHEMBL4782382
Type:
Small organic molecule
Emp. Form.:
C30H38N10O3
Mol. Mass.:
586.6879
SMILES:
CC#CCn1c(nc2n(C)c(=O)n(CCCN3CCN(CC3)c3noc(n3)-c3ccccc3)c(=O)c12)N1CCC[C@@H](N)C1 |r|
Structure:
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