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Target
Epoxide hydrolase 1
Ligand
BDBM50551716
Substrate
n/a
Meas. Tech.
ChEMBL_2032349 (CHEMBL4686507)
IC50
10±n/a nM
Citation
 Barnych, B; Singh, N; Negrel, S; Zhang, Y; Magis, D; Roux, C; Hua, X; Ding, Z; Morisseau, C; Tantillo, DJ; Siegel, JB; Hammock, BD Development of potent inhibitors of the human microsomal epoxide hydrolase. Eur J Med Chem 193:0 (2020) [PubMed]  Article 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM50551716
Synonyms:
CHEMBL4744212
Type:
Small organic molecule
Emp. Form.:
C15H17F4NOS
Mol. Mass.:
335.36
SMILES:
NC(=O)C(SCc1ccc(F)c(c1)C(F)(F)F)C1CCCC1
Structure:
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