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Target
ATP-dependent RNA helicase DDX3X
Ligand
BDBM50552034
Substrate
n/a
Meas. Tech.
ChEMBL_2033055 (CHEMBL4687213)
IC50
140±n/a nM
Citation
 Brai, A; Riva, V; Saladini, F; Zamperini, C; Trivisani, CI; Garbelli, A; Pennisi, C; Giannini, A; Boccuto, A; Bugli, F; Martini, M; Sanguinetti, M; Zazzi, M; Dreassi, E; Botta, M; Maga, G DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins. Eur J Med Chem 200:0 (2020) [PubMed]  Article 
Target
Name:
ATP-dependent RNA helicase DDX3X
Synonyms:
DBX | DDX3 | DDX3X | DDX3X_HUMAN
Type:
PROTEIN
Mol. Mass.:
73247.61
Organism:
Homo sapiens (Human)
Description:
ChEMBL_811954
Residue:
662
Sequence:
MSHVAVENALGLDQQFAGLDLNSSDNQSGGSTASKGRYIPPHLRNREATKGFYDKDSSGWSSSKDKDAYSSFGSRSDSRGKSSFFSDRGSGSRGRFDDRGRSDYDGIGSRGDRSGFGKFERGGNSRWCDKSDEDDWSKPLPPSERLEQELFSGGNTGINFEKYDDIPVEATGNNCPPHIESFSDVEMGEIIMGNIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIYSDGPGEALRAMKENGRYGRRKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYGGADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRMLDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIFLAVGRVGSTSENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLEDFLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARGLDISNVKHVINFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEAKQEVPSWLENMAYEHHYKGSSRGRSKSSRFSGGFGARDYRQSSGASSSSFSSSRASSSRSGGGGHGSSRGFGGGGYGGFYNSDGYGGNYNSQGVDWWGN
  
Inhibitor
Name:
BDBM50552034
Synonyms:
CHEMBL4743218
Type:
Small organic molecule
Emp. Form.:
C25H31N5O2
Mol. Mass.:
433.5459
SMILES:
CCCCc1cn(nn1)-c1ccc(NC(=O)Nc2cc(OC3CCCC3)ccc2C)cc1
Structure:
Search PDB for entries with ligand similarity: