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Target
Tubulin beta-2B chain
Ligand
BDBM50111554
Substrate
n/a
Meas. Tech.
ChEMBL_225810 (CHEMBL845250)
IC50
870.0±n/a nM
Citation
 Wang, L; Woods, KW; Li, Q; Barr, KJ; McCroskey, RW; Hannick, SM; Gherke, L; Credo, RB; Hui, YH; Marsh, K; Warner, R; Lee, JY; Zielinski-Mozng, N; Frost, D; Rosenberg, SH; Sham, HL Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure-activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation. J Med Chem 45:1697-711 (2002) [PubMed]  Article 
Target
Name:
Tubulin beta-2B chain
Synonyms:
TBB2B_BOVIN | TUBB2B | Tubulin | Tubulin beta chain
Type:
PROTEIN
Mol. Mass.:
49932.38
Organism:
Bos taurus
Description:
ChEMBL_211651
Residue:
445
Sequence:
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA
  
Inhibitor
Name:
BDBM50111554
Synonyms:
CHEMBL296066 | Dimethyl-{4-[4-(3,4,5-trimethoxy-phenyl)-oxazol-5-yl]-phenyl}-amine
Type:
Small organic molecule
Emp. Form.:
C20H22N2O4
Mol. Mass.:
354.3997
SMILES:
COc1cc(cc(OC)c1OC)-c1ncoc1-c1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: