Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50111631
Substrate
n/a
Meas. Tech.
ChEBML_201567
Ki
5±n/a nM
Citation
 Mouithys-Mickalad, A; Poupaert, JH; Spampinato, S; Lesieur, D Synthesis and pharmacological evaluation of 6-piperidino- and 6-piperazinoalkyl-2(3H)-benzothiazolones as mixed sigma/5-HT(1A) ligands. Bioorg Med Chem Lett 12:1149-52 (2002) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50111631
Synonyms:
6-[2-(4-Benzyl-piperidin-1-yl)-ethyl]-3-methyl-3H-benzothiazol-2-one | CHEMBL15809
Type:
Small organic molecule
Emp. Form.:
C22H26N2OS
Mol. Mass.:
366.52
SMILES:
Cn1c2ccc(CCN3CCC(Cc4ccccc4)CC3)cc2sc1=O
Structure:
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