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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50552483
Substrate
n/a
Meas. Tech.
ChEMBL_2034631 (CHEMBL4688789)
IC50
74000±n/a nM
Citation
 Gurusingha Arachchige, HS; Herath Mudiyanselage, PDH; VanHecke, GC; Patel, K; Cheaito, HA; Dou, QP; Ahn, YH Synthesis and evaluation of tiaprofenic acid-derived UCHL5 deubiquitinase inhibitors. Bioorg Med Chem 30:0 (2021) [PubMed]  Article 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM50552483
Synonyms:
CHEMBL4763594
Type:
Small organic molecule
Emp. Form.:
C23H18N4O4
Mol. Mass.:
414.4134
SMILES:
Nc1ccc(cc1)-c1cn(Cc2cc(cc(c2)-c2cccc(c2)C(O)=O)C(O)=O)nn1
Structure:
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