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Target
Tubulin alpha-1A chain
Ligand
BDBM50112256
Substrate
n/a
Meas. Tech.
ChEMBL_225980 (CHEMBL854763)
IC50
170±n/a nM
Citation
 Wipf, P; Reeves, JT; Balachandran, R; Day, BW Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. J Med Chem 45:1901-17 (2002) [PubMed]  Article 
Target
Name:
Tubulin alpha-1A chain
Synonyms:
TBA1A_PIG | TUBA1A | Tubulin | Tubulin alpha chain | Tubulin alpha-1A chain
Type:
Protein
Mol. Mass.:
50049.25
Organism:
Sus scrofa (Pig)
Description:
P02550
Residue:
451
Sequence:
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRAHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVDSVEGEGEEEGEEY
  
Inhibitor
Name:
BDBM50112256
Synonyms:
3,4,5-Trimethoxy-benzaldehyde O-(8-hydroxy-5-methyl-8-thiophen-2-yl-octa-2,4-dienyl)-oxime | CHEMBL56812
Type:
Small organic molecule
Emp. Form.:
C23H29NO5S
Mol. Mass.:
431.545
SMILES:
COc1cc(\C=N/OC\C=C\C=C(/C)CCC(O)c2cccs2)cc(OC)c1OC
Structure:
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