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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50552746
Substrate
n/a
Meas. Tech.
ChEMBL_2035373 (CHEMBL4689531)
Ki
0.090000±n/a nM
Citation
 Abdel-Magid, AF Myeloid Cell Leukemia-1 Inhibitors as Emerging Cancer Treatment. ACS Med Chem Lett 12:334-336 (2021) [PubMed]  Article 
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50552746
Synonyms:
CHEMBL4759259
Type:
Small organic molecule
Emp. Form.:
C39H51ClFN5O5S
Mol. Mass.:
756.369
SMILES:
[H][C@]12COCCN1CCN(C[C@@H]1N3CC[C@H]3CN3C[C@@]4(CCCc5cc(Cl)ccc45)COc4ccc(cc34)C(=O)NS(=O)(=O)[C@H](C)[C@@H](C)C\C=C1/F)C2 |r,t:55|
Structure:
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