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Target
Histone deacetylase 2
Ligand
BDBM50552915
Substrate
n/a
Meas. Tech.
ChEMBL_2035434 (CHEMBL4689592)
IC50
27000±n/a nM
Citation
 Stott, AJ; Maillard, MC; Beaumont, V; Allcock, D; Aziz, O; Borchers, AH; Blackaby, W; Breccia, P; Creighton-Gutteridge, G; Haughan, AF; Jarvis, RE; Luckhurst, CA; Matthews, KL; McAllister, G; Pollack, S; Saville-Stones, E; Van de Poël, AJ; Vater, HD; Vann, J; Williams, R; Yates, D; Muñoz-Sanjuán, I; Dominguez, C Evaluation of 5-(Trifluoromethyl)-1,2,4-oxadiazole-Based Class IIa HDAC Inhibitors for Huntington's Disease. ACS Med Chem Lett 12:380-388 (2021) [PubMed]  Article 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM50552915
Synonyms:
CHEMBL4798111
Type:
Small organic molecule
Emp. Form.:
C18H21F3N4O2
Mol. Mass.:
382.3801
SMILES:
C[C@H](CN1CCC[C@@H]1C)NC(=O)c1ccc(cc1)-c1noc(n1)C(F)(F)F |r|
Structure:
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