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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50553041
Substrate
n/a
Meas. Tech.
ChEMBL_2035619 (CHEMBL4689777)
Ki
3.0±n/a nM
Citation
 Zhang, X; Zhu, B; Guo, L; Bakaj, I; Rankin, M; Ho, G; Kauffman, J; Lee, SP; Norquay, L; Macielag, MJ Discovery of a Novel Series of Pyridone-Based EP3 Antagonists for the Treatment of Type 2 Diabetes. ACS Med Chem Lett 12:451-458 (2021) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50553041
Synonyms:
CHEMBL4779295
Type:
Small organic molecule
Emp. Form.:
C23H23FN4O4
Mol. Mass.:
438.4515
SMILES:
CCn1ncc2c(F)cc(cc12)-c1ccc(c(=O)[nH]1)C(CC)(CC)\C=C1/OC(=O)NC1=O
Structure:
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