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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50553011
Substrate
n/a
Meas. Tech.
ChEMBL_2035638 (CHEMBL4689796)
Ki
1.000000±n/a nM
Citation
 Zhang, X; Zhu, B; Guo, L; Bakaj, I; Rankin, M; Ho, G; Kauffman, J; Lee, SP; Norquay, L; Macielag, MJ Discovery of a Novel Series of Pyridone-Based EP3 Antagonists for the Treatment of Type 2 Diabetes. ACS Med Chem Lett 12:451-458 (2021) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_RAT | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor | Ptger3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39958.37
Organism:
RAT
Description:
Prostaglandin E2 PTGER2 RAT::P34980
Residue:
365
Sequence:
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
  
Inhibitor
Name:
BDBM50553011
Synonyms:
CHEMBL4791261
Type:
Small organic molecule
Emp. Form.:
C23H19FN2O4
Mol. Mass.:
406.4064
SMILES:
CC(C)C(\C=C1/OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2cccc(F)c2c1
Structure:
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