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Target
Equilibrative nucleoside transporter 1
Ligand
BDBM429521
Substrate
n/a
Meas. Tech.
ChEMBL_2045081 (CHEMBL4699780)
IC50
190±n/a nM
Citation
 Correia, C; Xavier, CPR; Duarte, D; Ferreira, A; Moreira, S; Vasconcelos, MH; Vale, N Development of potent CPP6-gemcitabine conjugates against human prostate cancer cell line (PC-3). RSC Med Chem 11:268-273 (2020) [PubMed]  Article 
Target
Name:
Equilibrative nucleoside transporter 1
Synonyms:
ENT1 | Equilibrative NBMPR-sensitive nucleoside transporter | Equilibrative Nucleoside Transporter 1 (ENT1) | Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter | Equilibrative nucleoside transporter 1 | Nucleoside transporter, es-type | S29A1_HUMAN | SLC29A1 | Solute carrier family 29 member 1
Type:
Multi-pass membrane protein
Mol. Mass.:
50225.92
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
456
Sequence:
MTTSHQPQDRYKAVWLIFFMLGLGTLLPWNFFMTATQYFTNRLDMSQNVSLVTAELSKDAQASAAPAAPLPERNSLSAIFNNVMTLCAMLPLLLFTYLNSFLHQRIPQSVRILGSLVAILLVFLITAILVKVQLDALPFFVITMIKIVLINSFGAILQGSLFGLAGLLPASYTAPIMSGQGLAGFFASVAMICAIASGSELSESAFGYFITACAVIILTIICYLGLPRLEFYRYYQQLKLEGPGEQETKLDLISKGEEPRAGKEESGVSVSNSQPTNESHSIKAILKNISVLAFSVCFIFTITIGMFPAVTVEVKSSIAGSSTWERYFIPVSCFLTFNIFDWLGRSLTAVFMWPGKDSRWLPSLVLARLVFVPLLLLCNIKPRRYLTVVFEHDAWFIFFMAAFAFSNGYLASLCMCFGPKKVKPAEAETAGAIMAFFLCLGLALGAVFSFLFRAIV
  
Inhibitor
Name:
BDBM429521
Synonyms:
med.21724, Compound Gemcitabine
Type:
Small Organic Molecule
Emp. Form.:
C9H11F2N3O4
Mol. Mass.:
263.1981
SMILES:
Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)C2(F)F)c(=O)n1
Structure:
Search PDB for entries with ligand similarity: