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Target
Mitogen-activated protein kinase 1
Ligand
BDBM50553103
Substrate
n/a
Meas. Tech.
ChEMBL_2045148 (CHEMBL4699847)
IC50
>100000±n/a nM
Citation
 Rachman, M; Bajusz, D; Hetényi, A; Scarpino, A; Mer?, B; Egyed, A; Buday, L; Barril, X; Keser?, GM Discovery of a novel kinase hinge binder fragment by dynamic undocking. RSC Med Chem 11:552-558 (2020) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM50553103
Synonyms:
CHEMBL4784866
Type:
Small organic molecule
Emp. Form.:
C9H8N2O
Mol. Mass.:
160.1726
SMILES:
Nc1cccc2cc[nH]c(=O)c12
Structure:
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