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Target
Arginase-1
Ligand
BDBM50553165
Substrate
n/a
Meas. Tech.
ChEMBL_2045304 (CHEMBL4700003)
IC50
89000±n/a nM
Citation
 Muller, J; Cardey, B; Zedet, A; Desingle, C; Grzybowski, M; Pomper, P; Foley, S; Harakat, D; Ramseyer, C; Girard, C; Pudlo, M Synthesis, evaluation and molecular modelling of piceatannol analogues as arginase inhibitors. RSC Med Chem 11:559-568 (2020) [PubMed]  Article 
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50553165
Synonyms:
CHEMBL4754674
Type:
Small organic molecule
Emp. Form.:
C13H13NO4
Mol. Mass.:
247.2466
SMILES:
Oc1ccc(CNc2ccc(O)c(O)c2)cc1O
Structure:
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