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Target
C-C chemokine receptor type 5
Ligand
BDBM50104943
Substrate
n/a
Meas. Tech.
ChEMBL_49996 (CHEMBL661336)
Ki
58±n/a nM
Citation
 Palani, A; Shapiro, S; Josien, H; Bara, T; Clader, JW; Greenlee, WJ; Cox, K; Strizki, JM; Baroudy, BM Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti-HIV activity. J Med Chem 45:3143-60 (2002) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | CC-CKR-5 | CCR-5 | CCR5_MOUSE | CD_antigen=CD195 | Ccr5 | Cmkbr5 | MIP-1 alpha receptor
Type:
PROTEIN
Mol. Mass.:
40803.93
Organism:
Mus musculus
Description:
ChEMBL_49996
Residue:
354
Sequence:
MDFQGSVPTYSYDIDYGMSAPCQKINVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSVTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKVRTVNFGVITSVVTWAVAVFASLPEIIFTRSQKEGFHYTCSPHFPHTQYHFWKSFQTLKMVILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEFFGLNNCSSSNRLDQAMQATETLGMTHCCLNPVIYAFVGEKFRSYLSVFFRKHMVKRFCKRCSIFQQDNPDRASSVYTRSTGEHEVSTGL
  
Inhibitor
Name:
BDBM50104943
Synonyms:
4-[(4-Bromophenyl)methyl]-1'-(2,6-dimethylbenzoyl)-4'-methyl-1,4'-bipiperidine | CHEMBL106247 | [4-(4-Bromo-benzyl)-4'-methyl-[1,4']bipiperidinyl-1'-yl]-(2,6-dimethyl-phenyl)-methanone
Type:
Small organic molecule
Emp. Form.:
C27H35BrN2O
Mol. Mass.:
483.484
SMILES:
Cc1cccc(C)c1C(=O)N1CCC(C)(CC1)N1CCC(Cc2ccc(Br)cc2)CC1
Structure:
Search PDB for entries with ligand similarity: