Reaction Details Report a problem with these data
Target
Dedicator of cytokinesis protein 5
Ligand
BDBM50554779
Substrate
n/a
Meas. Tech.
ChEMBL_2050578 (CHEMBL4705277)
IC50
43000±n/a nM
Citation
Mounier, L; Morel, A; Ferrandez, Y; Morko, J; Vääräniemi, J; Gilardone, M; Roche, D; Cherfils, J; Blangy, A Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation. J Med Chem 63:13680-13694 (2020) [PubMed] Article
More Info.:
Target
Name:
Dedicator of cytokinesis protein 5
Synonyms:
DOCK5_MOUSE | Dedicator of cytokinesis protein 5 | Dock5 | Lens rupture protein 2 | Lr2 | Rlc | Rlc GN | Rupture of lens cataract protein | Synonyms=Lr2
Type:
PROTEIN
Mol. Mass.:
214447.93
Organism:
Mus musculus
Description:
ChEMBL_120130
Residue:
1868
Sequence:
MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYALQNRSKKGIFPETYIHLKEATVEDGGQHETVIPGELPLVQELTNTLREWAVIWRKLYVNNKVTLFRQLQQMTYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETSTVALFRAHEVASKRIEEKIQEEKSILQNLDLRGQAIFSTVHTYGLYVNFKNFVCNIGEDAELFIALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSTDLIRPRISLVCQIVRVGRMELKEGKKHTCGLRRPFGVAVMDISDIVHGKVDDEEKQHFIPFQQIAMETYIRQRQLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHLVDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVFDEEGNLLEKAIHPGAGYEGVSEYKSVVYYQVKQPCWYETVKVFIAIEEVTRCHIRFTFRHRSSQESRDKSERAFGVAFVKLMNADGTTLQDGRHDLVVYKGDNKKMEDAKYYLTLPGTKAELEEKELQASKNPSVFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEVDGGEIVKFLQDTLDALFNIMMEMSDNETYDFLVFDALVFIISLIGDIKFQHFNPVLETYIYKHFSATLAHVKLSKVLNFYVANAEDPSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQSEDGDEFNDSIRQLFLAFNTLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPMELSVLFCKFIQSIPDNQLVRQKLNCMTKIVESSLFQQAECREVLLPLLTDQLSGQLDDHSTKPDHEASSQLLSNILEVLDRTDVGPTSAHVQLIMERLLRRINRTVIGMSRQSPHIGSFVACMIAVLRQMEDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRAINQFAEVLTKSFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSEAKRNKIVKKYGDMRKEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNLSGNGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLANSGEAFAFLVSSLLENLLDYRTIIIHDESKENRMSCTVNVLNFYKDKKREDIYIRYLYKLRDLHRDCENYTEAAYTLLLHAELLQWSDKPCVPHLLQRDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKLSKELAETYESKVFDYEGLGSLLKKRALFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKIFIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYLQCFTVKPVMSLPPSYKDKPVPEQILNYYRANEVQQFSYSRPFRKGEKDPENEFATMWIERTTYRTAYTFPGILKWFEAKEISVEEISPLENAIETMELTNERVSNCVQQHAWDHSLSVHPLSMLLSGIVDPAVMGGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQIPLLTEGIRIHGEKLTEQLKPLHARLSSCFRELKEKVEKLYGVITLPPSMTERKPSRAGSMVLPYILSSTLRRLSVTSVASSVISTSSNSSDNASSRPGSDGSILEPLFERRASSGARVEDLPPKEDSENRISKFKRKDWNLSKSQVIAEKAPEPDVMSPGKKTQRPKSLQLVDSRLTPFHSPSPLQSTALSPPPLTPKATRTLSSPSLQTDGLTASVPPPPPPKSKPYESSQRNSAEIAPPLPVRRDSKAPPPPPPKARKSGILSSEPGSQ