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Target
G-protein coupled receptor 52
Ligand
BDBM50554924
Substrate
n/a
Meas. Tech.
ChEMBL_2050975 (CHEMBL4705674)
EC50
850±n/a nM
Citation
 Wang, P; Felsing, DE; Chen, H; Stutz, SJ; Murphy, RE; Cunningham, KA; Allen, JA; Zhou, J Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior. J Med Chem 63:13951-13972 (2020) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 52
Synonyms:
GPR52 | GPR52_HUMAN | Probable G-protein coupled receptor 52
Type:
PROTEIN
Mol. Mass.:
41366.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108391
Residue:
361
Sequence:
MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
  
Inhibitor
Name:
BDBM50554924
Synonyms:
CHEMBL4746394 | US20240059655, Compound PW0896
Type:
Small organic molecule
Emp. Form.:
C24H26N4O4
Mol. Mass.:
434.4876
SMILES:
COc1cc(Cc2cc(ncn2)N2CCc3c2cccc3C(=O)NCCO)cc(OC)c1
Structure:
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