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Target
G-protein coupled receptor 52
Ligand
BDBM50554926
Substrate
n/a
Meas. Tech.
ChEMBL_2050975 (CHEMBL4705674)
EC50
131±n/a nM
Citation
 Wang, P; Felsing, DE; Chen, H; Stutz, SJ; Murphy, RE; Cunningham, KA; Allen, JA; Zhou, J Discovery of Potent and Brain-Penetrant GPR52 Agonist that Suppresses Psychostimulant Behavior. J Med Chem 63:13951-13972 (2020) [PubMed]  Article 
Target
Name:
G-protein coupled receptor 52
Synonyms:
GPR52 | GPR52_HUMAN | Probable G-protein coupled receptor 52
Type:
PROTEIN
Mol. Mass.:
41366.15
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108391
Residue:
361
Sequence:
MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLSNSVFRLGLRRLSETMCTSCMCVKDQEAQEPKPRKRANSCSI
  
Inhibitor
Name:
BDBM50554926
Synonyms:
CHEMBL4756386 | US20240059655, Compound PW0890
Type:
Small organic molecule
Emp. Form.:
C23H21F3N4O3
Mol. Mass.:
458.433
SMILES:
OCCNC(=O)c1cccc2N(CCc12)c1cc(Cc2cccc(OC(F)(F)F)c2)ncn1
Structure:
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