Reaction Details Report a problem with these data
Target
Matrilysin
Ligand
BDBM50555049
Substrate
n/a
Meas. Tech.
ChEMBL_2051202 (CHEMBL4705901)
Ki
323±n/a nM
Citation
 Gona, K; Toczek, J; Ye, Y; Sanzida, N; Golbazi, A; Boodagh, P; Salarian, M; Jung, JJ; Rajendran, S; Kukreja, G; Wu, TL; Devel, L; Sadeghi, MM Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. J Med Chem 63:15037-15049 (2020) [PubMed]  Article 
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50555049
Synonyms:
CHEMBL4747528
Type:
Small organic molecule
Emp. Form.:
C17H24N2O5
Mol. Mass.:
336.3829
SMILES:
CC(C)C[C@H](CC(=O)NO)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r|
Structure:
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