Target
Fructose-1,6-bisphosphatase 1
Ligand
BDBM496934
Substrate
n/a
Meas. Tech.
ChEMBL_2053890 (CHEMBL4708891)
IC50
6640±n/a nM
Citation
 Xu, YXHuang, YYSong, RRRen, YLChen, XZhang, CMao, FLi, XKZhu, JNi, SSWan, JLi, J Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes. Eur J Med Chem 203:0 (2020) [PubMed]  Article 
Target
Name:
Fructose-1,6-bisphosphatase 1
Synonyms:
D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | F16P1_HUMAN | FBP | FBP1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1 | Fructose-1,6-bisphosphatase 1 (FBPase)
Type:
Protein
Mol. Mass.:
36843.58
Organism:
Homo sapiens (Human)
Description:
Liver FBPase (P09467)
Residue:
338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
  
Inhibitor
Name:
BDBM496934
Synonyms:
acs.jmedchem.1c00409_ST.249 | cmdc.202100576, 17b
Type:
Small organic molecule
Emp. Form.:
C10H9NS3
Mol. Mass.:
239.38
SMILES:
Cc1ccc(SSc2nccs2)cc1
Structure:
Search PDB for entries with ligand similarity: