Reaction Details Report a problem with these data
Target
Steroid hormone receptor ERR2
Ligand
BDBM50555949
Substrate
n/a
Meas. Tech.
ChEMBL_2054239 (CHEMBL4709240)
IC50
774±n/a nM
Citation
 Kim, J; Hwang, H; Yoon, H; Lee, JE; Oh, JM; An, H; Ji, HD; Lee, S; Cha, E; Ma, MJ; Kim, DS; Lee, SJ; Kadayat, TM; Song, J; Lee, SW; Jeon, JH; Park, KG; Lee, IK; Jeon, YH; Chin, J; Cho, SJ An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer. Eur J Med Chem 205:0 (2020) [PubMed]  Article 
Target
Name:
Steroid hormone receptor ERR2
Synonyms:
ERR beta-2 | ERR-beta | ERR2_HUMAN | ERRB2 | ESRL2 | ESRRB | Estrogen receptor-like 2 | Estrogen-related receptor beta | NR3B2 | Nuclear receptor subfamily 3 group B member 2 | Steroid hormone receptor ERR2 | Steroid hormone receptor ERR2 Beta
Type:
PROTEIN
Mol. Mass.:
48061.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_11254
Residue:
433
Sequence:
MSSDDRHLGSSCGSFIKTEPSSPSSGIDALSHHSPSGSSDASGGFGLALGTHANGLDSPPMFAGAGLGGTPCRKSYEDCASGIMEDSAIKCEYMLNAIPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRLDSESSPYLSLQISPPAKKPLTKIVSYLLVAEPDKLYAMPPPGMPEGDIKALTTLCDLADRELVVIIGWAKHIPGFSSLSLGDQMSLLQSAWMEILILGIVYRSLPYDDKLVYAEDYIMDEEHSRLAGLLELYRAILQLVRRYKKLKVEKEEFVTLKALALANSDSMYIEDLEAVQKLQDLLHEALQDYELSQRHEEPWRTGKLLLTLPLLRQTAAKAVQHFYSVKLQGKVPMHKLFLEMLEAKV
  
Inhibitor
Name:
BDBM50555949
Synonyms:
CHEMBL4795846
Type:
Small organic molecule
Emp. Form.:
C31H35ClFNO
Mol. Mass.:
492.067
SMILES:
Cl.Oc1ccc(cc1)C(=C(/CCCF)c1ccccc1)\c1ccc(cc1)C1CCN(CC1)C1CC1
Structure:
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