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Target
Carbonic anhydrase 12
Ligand
BDBM50556094
Substrate
n/a
Meas. Tech.
ChEMBL_2054804 (CHEMBL4709805)
Ki
17±n/a nM
Citation
 Alkhaldi, AAM; Al-Sanea, MM; Nocentini, A; Eldehna, WM; Elsayed, ZM; Bonardi, A; Abo-Ashour, MF; El-Damasy, AK; Abdel-Maksoud, MS; Al-Warhi, T; Gratteri, P; Abdel-Aziz, HA; Supuran, CT; El-Haggar, R 3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies. Eur J Med Chem 207:0 (2020) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50556094
Synonyms:
CHEMBL4761395
Type:
Small organic molecule
Emp. Form.:
C17H15N5O3S2
Mol. Mass.:
401.463
SMILES:
Cc1c(NC(=O)Nc2ccc(cc2)S(N)(=O)=O)sc2nc3ccccc3n12
Structure:
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