Target
Lysophosphatidylserine lipase ABHD12
Ligand
BDBM50556533
Substrate
n/a
Meas. Tech.
ChEMBL_2056359 (CHEMBL4711360)
IC50
>10000±n/a nM
Citation
 Arena, CGado, FDi Cesare Mannelli, LCervetto, CCarpi, SReynoso-Moreno, IPolini, BVallini, EChicca, SLucarini, EBertini, SD'Andrea, FDigiacomo, MPoli, GTuccinardi, TMacchia, MGertsch, JMarcoli, MNieri, PGhelardini, CChicca, AManera, C The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. Eur J Med Chem 208:0 (2020) [PubMed]  Article 
Target
Name:
Lysophosphatidylserine lipase ABHD12
Synonyms:
ABD12_HUMAN | ABHD12 | C20orf22 | Monoacylglycerol lipase ABHD12
Type:
PROTEIN
Mol. Mass.:
45111.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514755
Residue:
398
Sequence:
MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
  
Inhibitor
Name:
BDBM50556533
Synonyms:
CHEMBL4781952
Type:
Small organic molecule
Emp. Form.:
C21H24ClFN2O2
Mol. Mass.:
390.879
SMILES:
Cc1c(Cl)cc(C(=O)NC2CCCCCC2)c(=O)n1Cc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: