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Target
Lysophosphatidylserine lipase ABHD12
Ligand
BDBM50556539
Substrate
n/a
Meas. Tech.
ChEMBL_2056359 (CHEMBL4711360)
IC50
>10000±n/a nM
Citation
 Arena, C; Gado, F; Di Cesare Mannelli, L; Cervetto, C; Carpi, S; Reynoso-Moreno, I; Polini, B; Vallini, E; Chicca, S; Lucarini, E; Bertini, S; D'Andrea, F; Digiacomo, M; Poli, G; Tuccinardi, T; Macchia, M; Gertsch, J; Marcoli, M; Nieri, P; Ghelardini, C; Chicca, A; Manera, C The endocannabinoid system dual-target ligand N-cycloheptyl-1,2-dihydro-5-bromo-1-(4-fluorobenzyl)-6-methyl-2-oxo-pyridine-3-carboxamide improves disease severity in a mouse model of multiple sclerosis. Eur J Med Chem 208:0 (2020) [PubMed]  Article 
Target
Name:
Lysophosphatidylserine lipase ABHD12
Synonyms:
ABD12_HUMAN | ABHD12 | C20orf22 | Monoacylglycerol lipase ABHD12
Type:
PROTEIN
Mol. Mass.:
45111.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514755
Residue:
398
Sequence:
MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
  
Inhibitor
Name:
BDBM50556539
Synonyms:
CHEMBL4750323
Type:
Small organic molecule
Emp. Form.:
C21H24BrFN2O7
Mol. Mass.:
515.327
SMILES:
CO[C@@H]1O[C@H](CNC(=O)c2cc(Br)c(C)n(Cc3ccc(F)cc3)c2=O)[C@H](O)[C@H](O)[C@H]1O |r|
Structure:
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