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Target
Glutathionylspermidine synthase
Ligand
BDBM50117547
Substrate
n/a
Meas. Tech.
ChEMBL_72744 (CHEMBL681931)
Ki
60000±n/a nM
Citation
 Amssoms, K; Oza, SL; Ravaschino, E; Yamani, A; Lambeir, A; Rajan, P; Bal, G; Rodriguez, J; Fairlamb, AH; Augustyns, K; Haemers, A Glutathione-like tripeptides as inhibitors of glutathionylspermidine synthetase. Part 1: Substitution of the glycine carboxylic acid group. Bioorg Med Chem Lett 12:2553-6 (2002) [PubMed]  Article 
Target
Name:
Glutathionylspermidine synthase
Synonyms:
GSP | GSP_CRIFA
Type:
PROTEIN
Mol. Mass.:
80299.94
Organism:
Crithidia fasciculata
Description:
ChEMBL_72759
Residue:
719
Sequence:
MSSLPHNHHYETHHRGTAEVPFDELIGVTPDGVPVISNGNEAHFSNLESITAACLPLSSFERKAPCKQPYRKMGVKWQCVEFVRRYLASRKAVWMTSLCTAEEVWREENLFVDVRDGRPVEVVRTPNKSTGPAPAVADIVVWGEGPETPFGHVAIVTEVCASCVRVAEQNQGFEKWPEDVPFSREIAMRTTESGEVELLDEDPLLGWVTVQAPFYNFDDGDLADSFRLVVGQGQILRQPFPKHVDVPWLNTGEECDTILKHSLVVDGNMGEGAHAEEGDVPGAFYFLDYDMFCRLGRAASSLHRIAMAATAKVLEDPESTHLLEHYFGVPPEIQPLLRRSWEMTPPMGGRFDFGYDGKNVVMLEYNCDSSGALLECCNTQEKMARFYGVSQGTSTGSFLGAKCVTYFQRLLTNEKVCPQHRLIHFMIDEDDEERYTARCMMGFAEQAGFRTKLCVKLVNFRYRDGPPSNAAPLATPCDHPTIVDGEDEEVLMVWKTWSWDTVLHQYHSQRSSSDAVNTPTLSDILLNNNIRVLEPLWKAVTGSKAILPFMHALAPDHEHMLAASFLPTREIISRHYISKPVNGRAGQNIMMYDPVTSPTELEGAPQQDICEALSQNASARSLLNGSPLPLSQSVDQTNECSPGKFFDSVLVYQQRLFLKKFDGKYFPIFCGWMVGDEFGGVVVREDTSKITKLSSMVVPARVVRDNVPLGVSYSDEGET
  
Inhibitor
Name:
BDBM50117547
Synonyms:
2-Amino-4-[3-methyl-1-(phosphonomethyl-carbamoyl)-butylcarbamoyl]-butyric acid | CHEMBL313808
Type:
Small organic molecule
Emp. Form.:
C12H24N3O7P
Mol. Mass.:
353.3086
SMILES:
CC(C)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCP(O)(O)=O
Structure:
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