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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50556689
Substrate
n/a
Meas. Tech.
ChEMBL_2056913 (CHEMBL4711914)
IC50
>50000±n/a nM
Citation
 Perrone, MG; Miciaccia, M; Vitale, P; Ferorelli, S; Araújo, CDCB; de Almeida, GS; Souza Domingos, TF; da Silva, LCRP; de Pádula, M; Cabral, LM; Sathler, PC; Bonaccorso, C; Fortuna, CG; Scilimati, A An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX1 | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | PGH1_SHEEP | PTGS1 | Prostaglandin G/H synthase (cyclooxygenase)
Type:
Protein
Mol. Mass.:
68868.60
Organism:
Ovis aries (Sheep)
Description:
n/a
Residue:
600
Sequence:
MSRQSISLRFPLLLLLLSPSPVFSADPGAPAPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPEIWTWLRTTLRPSPSFIHFLLTHGRWLWDFVNATFIRDTLMRLVLTVRSNLIPSPPTYNIAHDYISWESFSNVSYYTRILPSVPRDCPTPMDTKGKKQLPDAEFLSRRFLLRRKFIPDPQSTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQMLNGEVYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATIWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGAQFQYRNRIAMEFNQLYHWHPLMPDSFRVGPQDYSYEQFLFNTSMLVDYGVEALVDAFSRQPAGRIGGGRNIDHHILHVAVDVIKESRVLRLQPFNEYRKRFGMKPYTSFQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEMGAPFSLKGLLGNPICSPEYWKASTFGGEVGFNLVKTATLKKLVCLNTKTCPYVSFHVPDPRQEDRPGVERPPTEL
  
Inhibitor
Name:
BDBM50556689
Synonyms:
CHEMBL4791495
Type:
Small organic molecule
Emp. Form.:
C44H38N4O8
Mol. Mass.:
750.7945
SMILES:
COc1ccc(cc1)-c1noc(CC(=O)Nc2ccc(NC(=O)Cc3onc(c3-c3ccc(OC)cc3)-c3ccc(OC)cc3)cc2)c1-c1ccc(OC)cc1
Structure:
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