Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Ligand
BDBM50556732
Substrate
n/a
Meas. Tech.
ChEMBL_2057041 (CHEMBL4712042)
IC50
200±n/a nM
Citation
 Mostinski, YHeynen, GJJELópez-Alberca, MPPaul, JMiksche, SRadetzki, SSchaller, DShanina, ESeyffarth, CKolomeets, YZiebart, Nde Schryver, JOestreich, SNeuenschwander, MRoske, YHeinemann, URademacher, CVolkamer, Avon Kries, JPBirchmeier, WNazaré, M From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem 63:14780-14804 (2020) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms:
PP2AA_BOVIN | PPP2CA | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
PROTEIN
Mol. Mass.:
35586.74
Organism:
Bos taurus
Description:
ChEMBL_161787
Residue:
309
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL
  
Inhibitor
Name:
BDBM50556732
Synonyms:
CHEMBL4750435
Type:
Small organic molecule
Emp. Form.:
C30H20N2O5
Mol. Mass.:
488.4902
SMILES:
COc1ccc(cc1)-n1cc(-c2ccc3ccc(=O)oc3c2)c2cc(cnc12)-c1ccc(cc1)C(O)=O
Structure:
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