Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Ligand
BDBM50556732
Substrate
n/a
Meas. Tech.
ChEMBL_2057041 (CHEMBL4712042)
IC50
200±n/a nM
Citation
Mostinski, Y; Heynen, GJJE; López-Alberca, MP; Paul, J; Miksche, S; Radetzki, S; Schaller, D; Shanina, E; Seyffarth, C; Kolomeets, Y; Ziebart, N; de Schryver, J; Oestreich, S; Neuenschwander, M; Roske, Y; Heinemann, U; Rademacher, C; Volkamer, A; von Kries, JP; Birchmeier, W; Nazaré, M From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement. J Med Chem 63:14780-14804 (2020) [PubMed] Article
More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Synonyms:
PP2AA_BOVIN | PPP2CA | Serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
Type:
PROTEIN
Mol. Mass.:
35586.74
Organism:
Bos taurus
Description:
ChEMBL_161787
Residue:
309
Sequence:
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHVTRRTPDYFL