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Target
Acid ceramidase
Ligand
BDBM50431271
Substrate
n/a
Meas. Tech.
ChEMBL_2057396 (CHEMBL4712397)
IC50
12±n/a nM
Citation
 Caputo, S; Di Martino, S; Cilibrasi, V; Tardia, P; Mazzonna, M; Russo, D; Penna, I; Summa, M; Bertozzi, SM; Realini, N; Margaroli, N; Migliore, M; Ottonello, G; Liu, M; Lansbury, P; Armirotti, A; Bertorelli, R; Ray, SS; Skerlj, R; Scarpelli, R Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors. J Med Chem 63:15821-15851 (2020) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
AC | ACDase | ASAH1_RAT | Acid CDase | Acid ceramidase | Acid ceramidase (AC) | Acylsphingosine deacylase | Asah1 | N-acylsphingosine amidohydrolase
Type:
Enzyme
Mol. Mass.:
44450.22
Organism:
Rattus norvegicus (Rat)
Description:
Q6P7S1
Residue:
394
Sequence:
MLGRSLLTWVLAAAVTCAQAQQVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELLAHKAPVLRTLVNSISNLVNAFVPSGKIMQMVDEKLPGLIGSIPGPFGEEMRGIADVTGIPLGEIISFNIFYELFTMCTSIITEDGKGHLLHGRNMDFGIFLGWNINNNTWVVTEELKPLTVNLDFQRNNKTVFKATSFAGYVGMLTGFKPGLLSLTLNERFSLNGGYLGILEWMFGKKNAQWVGFITRSVLENSTSYEEAKNILTKTKITAPAYFILGGNQSGEGCVITRERKESLDVYELDPKHGRWYVVQTNYDRWKNTLFLDDRRTPAKKCLNHTTQKNLSFATIYDVLSTKPVLNKLTVFTTLIDVTKDQFESHLRDCPDPCIGW
  
Inhibitor
Name:
BDBM50431271
Synonyms:
CHEMBL2333033 | US9428465, 4
Type:
Small organic molecule
Emp. Form.:
C12H16F3N3O3
Mol. Mass.:
307.2689
SMILES:
CCCCCCNC(=O)n1cc(c(=O)[nH]c1=O)C(F)(F)F
Structure:
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