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Target
Signal transducer and activator of transcription 1
Ligand
BDBM549132
Substrate
n/a
Meas. Tech.
ChEMBL_2057508 (CHEMBL4712509)
IC50
>20000±n/a nM
Citation
 Brotherton-Pleiss, C; Yue, P; Zhu, Y; Nakamura, K; Chen, W; Fu, W; Kubota, C; Chen, J; Alonso-Valenteen, F; Mikhael, S; Medina-Kauwe, L; Tius, MA; Lopez-Tapia, F; Turkson, J Discovery of Novel Azetidine Amides as Potent Small-Molecule STAT3 Inhibitors. J Med Chem 64:695-710 (2021) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 1
Synonyms:
STAT1_MOUSE | Stat1
Type:
PROTEIN
Mol. Mass.:
87184.30
Organism:
Mus musculus
Description:
ChEMBL_863014
Residue:
749
Sequence:
MSQWFELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIYNCLKEERKILENAQRFNQAQEGNIQNTVMLDKQKELDSKVRNVKDQVMCIEQEIKTLEELQDEYDFKCKTSQNREGEANGVAKSDQKQEQLLLHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPNACLDQLQTWFTIVAETLQQIRQQLKKLEELEQKFTYEPDPITKNKQVLSDRTFLLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKSRLLVKLQESNLLTKVKCHFDKDVNEKNTVKGFRKFNILGTHTKVMNMEESTNGSLAAELRHLQLKEQKNAGNRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVTEPRNLSFFLNPPCAWWSQLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTILELIKNDLLCLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDDPKRTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEMSRIVGPEFDSMMSTV
  
Inhibitor
Name:
BDBM549132
Synonyms:
BDBM50556940 | US11299480, Example 138
Type:
Small organic molecule
Emp. Form.:
C30H25F5N4O5S
Mol. Mass.:
648.6
SMILES:
Fc1c(F)c(F)c(c(F)c1F)S(=O)(=O)N1CC[C@@H]1C(=O)N(Cc1ccc(cn1)C1CCCCC1)c1ccc2C(=O)NC(=O)c2c1 |r|
Structure:
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