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Target
Cholesteryl ester transfer protein
Ligand
BDBM50118055
Substrate
n/a
Meas. Tech.
ChEMBL_48930 (CHEMBL665925)
IC50
>50000±n/a nM
Citation
 Durley, RC; Grapperhaus, ML; Hickory, BS; Massa, MA; Wang, JL; Spangler, DP; Mischke, DA; Parnas, BL; Fobian, YM; Rath, NP; Honda, DD; Zeng, M; Connolly, DT; Heuvelman, DM; Witherbee, BJ; Melton, MA; Glenn, KC; Krul, ES; Smith, ME; Sikorski, JA Chiral N,N-disubstituted trifluoro-3-amino-2-propanols are potent inhibitors of cholesteryl ester transfer protein. J Med Chem 45:3891-904 (2002) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50118055
Synonyms:
2-((3-(trifluoromethoxy)benzyl)(3-phenoxyphenyl)amino)-1-phenylethanol | 2-[(3-Phenoxy-phenyl)-(3-trifluoromethoxy-benzyl)-amino]-1-phenyl-ethanol | CHEMBL127265
Type:
Small organic molecule
Emp. Form.:
C28H24F3NO3
Mol. Mass.:
479.4903
SMILES:
OC(CN(Cc1cccc(OC(F)(F)F)c1)c1cccc(Oc2ccccc2)c1)c1ccccc1
Structure:
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